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Medical Science Monitor Basic Research


Colon Adenocarcinoma Associated with Synchronous Extramural Gastrointestinal Stromal Tumor (GIST) of the Ileum

Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare co-existance of disease or pathology

Paschalis Gavriilidis, Anastasia Nikolaidou

Greece Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece

Am J Case Rep 2015; 16:837-839

DOI: 10.12659/AJCR.894845

Available online:

Published: 2015-11-26


BACKGROUND: GISTs are mesenchymal tumors representing approximately 1% of all gastrointestinal neoplasia. Their concurrence with colorectal cancers is rare.
CASE REPORT: We present a case of coexistence of colon adenocarcinoma and GIST of the ileum in a 68-year-old white woman.
CONCLUSIONS: The coexistence of mesenchymal and epithelial neoplasia is very challenging; further research is needed to clarify the role of oncogenic mutations and signalling pathways in carcinogenesis of neoplasia of various histiogenic origins.

Keywords: Adenocarcinoma - surgery, Colectomy - methods, Colonic Neoplasms - surgery, Diagnosis, Differential, Follow-Up Studies, Gastrointestinal Stromal Tumors - surgery, Ileal Neoplasms - surgery, Ileum - surgery, Neoplasms, Multiple Primary