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Remission of Severe Myasthenia Gravis After Massive-Dose Vitamin D Treatment

Unusual or unexpected effect of treatment, Unexpected drug reaction , Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Flávio Adsuara Cadegiani

Endocrinology Unit, Corpometria, Brasilia, Brazil

Am J Case Rep 2016; 17:51-54

DOI: 10.12659/AJCR.894849

Available online:

Published: 2016-01-29


BACKGROUND: Vitamin D has been shown to be related to autoimmune diseases, such as multiple sclerosis and psoriasis. Correlations have been reported between vitamin D levels and prevalence and severity of other autoimmune disorders, and also between vitamin D therapy and disease improvement and remission.
CASE REPORT: This is a case report of a patient with severe and refractory myasthenia gravis (MG) who followed a “high-dose vitamin D treatment”, a massive-dose treatment (80 000 to 120 000 IU/day) promoted by a medical center in Brazil (but still not proven), and she had her first complete remission after this type of treatment with increased vitamin D serum levels (400 to 700 ng/mL).
CONCLUSIONS: This case report may reinforce the reported correlation between vitamin D level and disease severity and introduces a possible new use for vitamin D as a potential target for treating autoimmune diseases. We recommend large, double-blind, placebo-controlled, randomized studies using high-dose vitamin D treatment for refractory autoimmune diseases to reliably assess this pharmacotherapy target for these diseases.

Keywords: Female, Dose-Response Relationship, Drug, Humans, Middle Aged, Myasthenia Gravis - drug therapy, Remission Induction, Severity of Illness Index, Vitamin D - administration & dosage, Vitamins - administration & dosage



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