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Positive TTF-1 Expression in Malignant Mesothelioma: A Case Report

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Georg Richter, Holger Heidersdorf, Dieter Hirschfeld, Friedhelm Krebbel

Institute of Pathology, Hameln, Germany

Am J Case Rep 2016; 17:133-136

DOI: 10.12659/AJCR.895661

Available online:

Published: 2016-03-04

BACKGROUND: The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.
CASE REPORT: A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.
CONCLUSIONS: The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.

Keywords: Biomarkers, Tumor - metabolism, Lung Neoplasms - metabolism, Mesothelioma - metabolism, Nuclear Proteins - metabolism, Transcription Factors - metabolism