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04 August 2016 : Clinical Research  

Human Fetuin-A Rs4918 Polymorphism and its Association with Obesity in Healthy Persons and in Patients with Myocardial Infarction in Two Hungarian Cohorts

György TemesszentandrásiBE, Krisztián VörösEF, Bernadett MárkusEF, Zoltán BöröczB, Edit KaszásB, Zoltán ProhászkaCD, András FalusCD, Károly CsehADE, László KalabayACDEFG

DOI: 10.12659/MSM.896232

Med Sci Monit 2016; 22:2742-2750

Abstract

BACKGROUND: Human fetuin A (AHSG) has been associated with the development of obesity, insulin resistance, type 2 diabetes mellitus, and atherosclerosis. Observations on the role of AHSG rs4918 single-nucleotide polymorphism are contradictory. We investigated the association between variants of rs4918 and parameters of obesity, lipid status, tumor necrosis factor-α (TNFα), adipokines (adiponectin, resistin, leptin), and insulin resistance in healthy persons and in patients with previous myocardial infarction.

MATERIAL AND METHODS: This was a cross-sectional study comprising cohort 1 (81 healthy individuals) and cohort 2 (157 patients with previous myocardial infarction). We used the allele-specific KASP genotyping assay to detect rs4918 polymorphism.

RESULTS: In cohort 1, G-nucleotide carriers had significantly lower serum TNFα, adiponectin, and higher leptin concentrations than in non-G carriers. These differences, however, were not observed in cohort 2. In cohort 2, G-carriers had lower BMI and waist circumferences than in non-G carriers. The G allele was more frequent among lean than obese patients (RR=1.067, 95%CI=1.053–2.651, p=0.015). An association between BMI and rs4918 polymorphism was observed among patients without diabetes (CC/CG/GG genotypes: p=0.003, G vs. non-G allele: p=0.008) but not in diabetics. In addition, a strong linearity between BMI and the CC/CG/GG genotypes (association value: 4.416, p=0.036) and the frequency of the G allele (7.420, p=0.006) could be identified. In cohort 2, non-obese, non-diabetic G-carriers still had lower BMI and waist circumferences than in non-G carriers.

CONCLUSIONS: The rs4918 minor variant is associated with lower TNFα and adiponectin, higher leptin levels in healthy persons, and more favorable anthropomorphic parameters of obesity in cohort 2.

Keywords: Adiponectin - metabolism, Adipokines - metabolism, Aged, 80 and over, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Genetic Predisposition to Disease, Hungary, Leptin - blood, Myocardial Infarction - metabolism, Obesity - metabolism, Polymorphism, Single Nucleotide, Tumor Necrosis Factor-alpha - metabolism, alpha-2-HS-Glycoprotein - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750