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Medical Science Monitor Basic Research


Human Embryonic Stem Cell Therapy in Crohn’s Disease: A Case Report

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Unexpected drug reaction , Educational Purpose (only if useful for a systematic review or synthesis)

Geeta Shroff

India Stem Cell Therapy, Nutech Mediworld, New Delhi, India

Am J Case Rep 2016; 17:124-128

DOI: 10.12659/AJCR.896512

Available online:

Published: 2016-02-29

BACKGROUND: Crohn’s disease is a chronic inflammatory disease of the intestines, mainly the colon and ileum, related with ulcers and fistulae. It is estimated to affect 565 000 people in the United States. Currently available therapies, such as antibiotics, thiopurines, and anti-tumor necrosis factor-alpha agents, are only observed to reduce the complications associated with Crohn’s disease and to improve quality of life, but cannot cure the disease. Stem cell therapy appears to have certain advantages over conventional therapies. Our study aimed to evaluate the efficacy of human embryonic stem cell therapy in a patient with Crohn’s disease.
CASE REPORT: A 21-year-old male with chief complaints of intolerance to specific foods, abdominal pain, and diarrhea underwent human embryonic stem cell therapy for two months. After undergoing human embryonic stem cell therapy, the patient showed symptomatic relief. He had no complaints of back pain, abdominal pain, or diarrhea and had improved digestion. The patient had no signs and symptoms of skin infection, and had improved limb stamina, strength, and endurance. The condition of patient was stable after the therapy.
CONCLUSIONS: Human embryonic stem cell therapy might serve as a new optimistic treatment approach for Crohn’s disease.

Keywords: Embryonic Stem Cells - transplantation, Crohn Disease - therapy, young adult