25 April 2016: Articles 
Mismatch Between Cardiac Perfusion, Sympathetic Innervation, and Left Ventricular Electroanatomical Map in a Patient with Recurrent Ventricular Tachycardia
Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Christiane Jungen ABCDEF , Gwendolyn von Gogh ABCDF , Christiane Schmitt ABCDF , Pawel Kuklik BCDEF , Boris Hoffmann ABCDF , Kenichi Nakajima ACDF , Stephan Willems ACDEF , Janos Mester ABCDEF , Christian Meyer ABCDEFDOI: 10.12659/AJCR.897412
Am J Case Rep 2016; 17:280-282
Abstract
BACKGROUND: Regional cardiac sympathetic denervation causes electrophysiological heterogeneity and has been found to be a predictor of potentially lethal VT.
CASE REPORT: We present the case of 69-year-old patient admitted with recurrent ventricular tachycardia and a history of anterior myocardial infarction. In line with Tc-99m-MIBI-SPECT perfusion imaging, electroanatomical mapping revealed extensive LV anterior scarring as detected by low-voltage areas. Surprisingly, I-123-MIBG-SPECT showed an extensive deficit of sympathetic innervation inferior (mismatch) and anterolateral (match).
CONCLUSIONS: Combination of electroanatomical mapping with tomographic imaging of innervation and perfusion might improve our understanding of the neural trigger of VT after myocardial infarction or substrate-based catheter ablation.
Keywords: Heart - innervation, Heart Ventricles - diagnostic imaging, myocardial perfusion imaging, Sympathetic Nervous System - physiopathology, Tachycardia, Ventricular - physiopathology, Tomography, Emission-Computed, Single-Photon
Background
Regional cardiac sympathetic denervation causes electrophysiological heterogeneity and has been found to be a predictor of potentially lethal VT.
Case Report
A 69-year-old male patient with a history of anterior myocardial infarction in 1988 presented with recurrent ventricular tachycardia (VT) that had to be terminated by multiple shocks of his implantable cardioverter defibrillator. A left ventricular (LV) apex aneurysm and a low LV ejection fraction were confirmed in echocardiography. Resting Tc-99m-MIBI-SPECT reflected the anterior myocardial scar with corresponding perfusion deficit (Figure 1A) which are presented 3-dimensionally (3D) (left column: anterior view; middle column: posterior view) and as polar plot (right column). No high-grade coronary stenosis was found in coronary angiography. I-123-MIBG-SPECT 4 hours after intravenous injection [1] (Figure 1B) showed an extensive deficit of sympathetic innervation inferior (mismatch,#) and anterolateral (match). However, residual innervation could be documented in a basal anterolateral region with severely impaired perfusion (reverse mismatch,*). Electroanatomical mapping (by using image integration with fluoroscopy), in line with perfusion, supported extensive LV anterior scarring as detected by low-voltage areas (Figure 1C). Note also the electroanatomical polar plot (custom-made software) supporting scarring in the left anterior descending coronary artery perfusion area. Substrate-based ablation was performed within the anterior myocardial scarring (low-voltage areas) [2]. Despite abolition of all signals indicating local abnormal ventricular activation, the patient again experienced a VT of midseptal origin (207 bpm, cycle length 290 ms) remote from the myocardial scar, which had to be additionally treated by radiofrequency catheter ablation.
Discussion
Denervation of inferior areas is known to occur in patients after modulating parts of the autonomic/sympathetic intracardiac nervous system located at the posterior wall of the left atrium during pulmonary vein isolation [3]. The present sympathetic innervation of the anterior non-perfused scar area might mirror a partial re-innervation 27 years after myocardial infarction. Regional cardiac sympathetic denervation causes electrophysiological heterogeneity in the myocardium [4,5] and has been found to be a predictor of potentially lethal VT [6–8]. Inhomogeneity in LV sympathetic innervation has also been described in areas remote from post-myocardial infarction scarring but is yet not fully understood [9].
Conclusions
Combination of electroanatomical mapping with tomographic imaging of innervation and perfusion might improve our understanding of the neural trigger of VT after myocardial infarction or substrate-based catheter ablation.
References:
1.. Nakajima K, Nakata T, Cardiac I-123-MIBG imaging for clinical decision making: 22-year experience in Japan: J Nucl Med, 2015; 56; 11S-19S, pmid: 26033897
2.. Jaïs P, Maury P, Khairy P, Sacher F, Elimination of local abnormal ventricular activities: A new end point for substrate modification in patients with scar-related ventricular tachycardia: Circulation, 2012; 125; 2184-96, pmid: 22492578
3.. Wenning C, Lange PS, Schülke C, Pulmonary vein isolation in patients with paroxysmal atrial fibrillation is associated with regional cardiac sympathetic denervation: EJNMMI Res, 2013; 3; 81, pmid: 24360192
4.. Meyer C, Rana OR, Saygili E, Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation: Circulation, 2010; 121; 1286-94, pmid: 20212280
5.. Lautamaki R, Sasano T, Higuchi T, Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone: J Nucl Med, 2015; 56; 457-63, pmid: 25635137
6.. Fallavollita JA, Heavey BM, Luisi AJ, Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy: J Am Coll Cardiol, 2014; 63; 141-49, pmid: 24076296
7.. Zipes DP, Sympathetic stimulation and arrhythmias: N Engl J Med, 1991; 325; 656-57, pmid: 1861701
8.. Meyer C, Carvalho P, Brinkmeyer C, Wearable sensors in syncope management: Med Sci Monit, 2015; 21; 276-82, pmid: 25608536
9.. Fallavollita JA, Canty JM, Dysinnervated but viable myocardium in ischemic heart disease: J Nucl Cardiol, 2010; 17; 1107-15, pmid: 20857351
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