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25 July 2016 : Case report  South Korea

Angioimmunoblastic T-Cell Lymphoma in a Patient with Klinefelter Syndrome

Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Congenital defects / diseases, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Yong Tae ParkABCDEF, Chan-Ho ParkAE, Mi Ae BaeAE, Hwa Sik JungAE, Youn Im LeeAE, Ji-Hun LimABCD, Hee Jeong ChaABCD, Min Jung SeoAD, Seol Hoon ParkABD, Yunsuk ChoiDE, Hawk KimE, Jae-Cheol JoABCDEF

DOI: 10.12659/AJCR.897572

Am J Case Rep 2016; 17:529-534

Abstract

BACKGROUND: Although patients with Klinefelter syndrome have elevated risk and incidence rates for several solid cancers, reports on the incidence of hematological malignancies have been equivocal.

CASE REPORT: We report a patient diagnosed with angioimmunoblastic T-cell lymphoma in whom Klinefelter syndrome was newly detected. Moreover, we discuss the development of a variety of lymphomas in patients with Klinefelter syndrome.

CONCLUSIONS: This is the first case describing angioimmunoblastic T-cell lymphoma in a patient with Klinefelter syndrome who was treated with chemotherapy.

Keywords: Immunoblastic Lymphadenopathy - therapy, Biopsy, Klinefelter Syndrome - diagnosis, Lymph Nodes - diagnostic imaging, Lymphoma, T-Cell - therapy, Tomography, X-Ray Computed

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923