12 October 2016 : Case report
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)Kyung Hyun KimE, Yun Hwa JungAE, Chi Wha HanE, In Sook WooE, Jong ho SonE
Am J Case Rep 2016; 17:734-738
BACKGROUND: Anaplastic large cell lymphoma (ALCL) is a relatively rare subtype of non-Hodgkin’s lymphoma (NHL). Like other types of NHL, ALCL primarily involves the nodal area, and sometimes it can involve several extra-nodal sites such as skin, soft tissue, and lungs. However, extensive bone involvement in cases of ALCL is very rare whether it is primary or secondary. Without nodular involvement, ALCL can be misdiagnosed as bone tumor or metastatic carcinoma such as lung, breast, or prostate cancer, which frequently spread to bone.
CASE REPORT: A 52-year-old woman with generalized pain and 2 months of fever of unknown origin presented to our institution. After extensive evaluation, only multiple osteolytic bone lesions with periosteal soft tissue reaction were identified. Repeated core needle biopsy revealed only inflammatory cells with histiocytic reactions. After pathologic and chromosomal analysis of sufficient tissue, which was acquired from incisional biopsy, primary bone ALCL was confirmed.
CONCLUSIONS: Clinicians should keep in mind that ALCL can present with extensive bone involvement without nodal involvement.
Keywords: Bone Neoplasms - pathology, Antineoplastic Combined Chemotherapy Protocols, Cyclophosphamide, Doxorubicin, Lymphoma, Large-Cell, Anaplastic - pathology, Prednisone, Tomography, X-Ray Computed, Vincristine, Whole Body Imaging
13 May 2022 : Case reportAcute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination
Am J Case Rep In Press; DOI: 10.12659/AJCR.936574
20 April 2022 : Case reportProgressive Worsening of Neurological Manifestations in HIV-Associated Opportunistic Central Nervous System...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936257
16 May 2022 : Case reportPrimary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level of Consciousne...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936401
16 May 2022 : Case reportLong-Term Efficacy of Dupilumab in Alopecia Areata
Am J Case Rep In Press; DOI: 10.12659/AJCR.936488
16 May 2022 : Case reportStellate Hypopigmentation in a Pediatric Patient After Treatment with Intralesionally-Injected Corticosteroid
Am J Case Rep In Press; DOI: 10.12659/AJCR.935898
Most Viewed Current Articles
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case reportMyocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...
Am J Case Rep 2022; 23:e934399
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406