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Dual Infection with Hepatitis B and Epstein-Barr Virus Presenting with Severe Jaundice, Coagulopathy, and Hepatitis B Virus Chronicity Outcome

Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Sirish C. Rao, Imran Ashraf, Fazia Mir, Sami Samiullah, Jamal A. Ibdah, Veysel Tahan

USA Department of Internal Medicine, University of Missouri Hospital , Columbia, MO, USA

Am J Case Rep 2017; 18:170-172

DOI: 10.12659/AJCR.901688

Available online: 2017-02-16

Published: 2017-02-16


BACKGROUND: Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV).
CASE REPORT: A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B.
CONCLUSIONS: To our knowledge, this patient case is the first reported case of HBV and EBV coinfection reported in the literature. HBV and EBV coinfection may cause severe acute hepatitis with HBV chronicity.

Keywords: Chronic Disease, coinfection, Epstein-Barr Virus Infections, Hepatitis B virus, Jaundice



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