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Adult-Onset Still’s Disease: Still a Serious Health Problem (a Case Report and Literature Review)

Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Mojgan Agha-Abbaslou, Ana Maria Bensaci, Oluchi Dike, Mark C. Poznansky, Arooj Hyat

(Division of Infectious Disease, Department of Medicine, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA, USA)

Am J Case Rep 2017; 18:119-124

DOI: 10.12659/AJCR.901846

Available online:

Published: 2017-02-03

BACKGROUND: Adult-onset Still’s Disease (AOSD) is a rare systemic inflammatory disease accompanied by a triad of spiking fever, maculopapular exanthema, and arthralgia. To date, there is no definite laboratory or imaging test available for diagnosing AOSD, and the diagnosis is one of exclusion, which can be very challenging.
CASE REPORT: We report on the case of a 53-year-old female who presented with fever, arthralgia, and abdominal pain. Her initial laboratory tests showed elevated AST and ALT, and normal leukocytes with bandemia. During her hospitalization, we evaluated the patient for other potential differential diagnoses. After an extensive workup, the patient was diagnosed with AOSD based on Yamaguchi criteria. Her serum ferritin levels were measured and found to be markedly elevated, which is a non-specific finding in AOSD patients.
CONCLUSIONS: This case highlights the important role of a detailed history and physical examination for timely diagnosis of AOSD to prevent complications and improve patient’s prognosis.

Keywords: Abdominal Pain, Arthralgia, Exanthema, Ferritins, Still's Disease, Adult-Onset