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Medical Science Monitor Basic Research


Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure

Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Educational Purpose (only if useful for a systematic review or synthesis)

Divya Mirchandani, Rafia Jawed, Nayaab Khawar, Pramod Narula, Minnie John

USA Department of Pediatrics, New York Presbyterian Healthcare System – New York Methodist Hospital, Brooklyn, NY, USA

Am J Case Rep 2017; 18:381-385

DOI: 10.12659/AJCR.902418

Available online:

Published: 2017-04-10

BACKGROUND: Liver failure in the neonatal population is a life-threatening complication and has a wide array of etiologies, including infectious, immune-mediated, metabolic, or drug-induced. Although neonatal herpes simplex virus (HSV) hepatitis only accounts for 1% of all acute liver failures, it has an extremely aggressive clinical course that carries a mortality rate of 85%.
CASE REPORT: We report a rare case of disseminated neonatal HSV-2 with late presentation associated with fulminant liver failure. The patient recovered without obvious neurologic deficits or need for liver transplant.
CONCLUSIONS: This case study emphasizes and promotes awareness of early recognition and appropriate clinical management of neonatal HSV infection, and its positive outcome.

Keywords: Herpes Simplex, Infant, Newborn, Liver Failure, Acute