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Rapidly Developed Multiple Face and Neck Skin Cancers in a Patient with Sjögren’s Syndrome: A Case Report

Unusual clinical course, Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis)

Lean San Teh, Ji-Ching Lai, Je Chuan Lian

Division of Plastic Surgery, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan

Am J Case Rep 2017; 18:347-350

DOI: 10.12659/AJCR.902828

Available online:

Published: 2017-04-04

BACKGROUND: Sjögren’s syndrome is a chronic, systemic disorder of an autoimmune nature, and its primary etiopathogenetic events are not known. Previous studies have found elevated incidence of malignancies in patients with primary Sjögren’s syndrome. However, there are few reports regarding the association of Sjögren’s syndrome with skin cancers, especially with multiple skin cancers developed within a short time.
CASE REPORT: We reported an unusual case of a patient with primary Sjögren’s syndrome who suffered from rapidly developed facial and neck skin cancers within two years.
CONCLUSIONS: Sjögren’s syndrome associated with skin cancer is rare. Our case report suggests that Sjögren’s syndrome patients require continuous follow-up with conventional cancer examination, including skin biopsy for suspected skin lesions.

Keywords: Head and Neck Neoplasms, Sjogren's Syndrome, Skin Neoplasms, Autoimmune Diseases