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Medical Science Monitor Basic Research


Primary Pituitary Tuberculosis Revisited

Mistake in diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Fatma Ben Abid, Mohammed Abukhattab, Hanfa Karim, Mohamed Agab, Issam Al-Bozom, Wanis H. Ibrahim

Qatar Division of Infectious Disease, Department of Medicine, Hamad General Hospital, Doha, Qatar

Am J Case Rep 2017; 18:391-394

DOI: 10.12659/AJCR.903233

Available online: 2017-04-12

Published: 2017-04-12


BACKGROUND: Primary pituitary tuberculosis (in absence of other organ involvement and constitutional symptoms) is an extremely rare disease with total reported cases in the literature fewer than a hundred. Misdiagnosis as pituitary adenoma is common and late diagnosis can result in a permanent endocrine dysfunction and/or long-term neurologic sequelae.
CASE REPORT: We report on the case of a middle-aged woman who presented with severe headache and left third cranial nerve palsy. Magnetic resonance imaging (MRI) revealed a large pituitary tumor invading the left cavernous sinus. The case was initially misdiagnosed as pituitary adenoma. A pituitary biopsy was performed and was suggestive of pituitary tuberculosis. Extensive radiologic investigations did not reveal any evidence of other organ involvement by tuberculosis. She was successfully treated with anti-tuberculous medications.
CONCLUSIONS: In areas with a high pre-test probability of tuberculosis, pituitary tuberculosis should be included in the differential diagnosis of pituitary tumors in order to avoid unnecessary surgical interventions. Besides being the first histologically-proven primary pituitary tuberculosis case reported from Qatar, the current case is unique in that extensive radiologic investigations did not reveal any evidence of other systemic or pulmonary tuberculosis.

Keywords: Pituitary Neoplasms, Tuberculosis, Central Nervous System, Tuberculosis, Endocrine