Kaposi Sarcoma in an Human Immunodeficiency Virus (HIV)-Seronegative Mediterranean Female: Report of a Rare Case
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease
Marios Grigoriou, Konstantinia E. Kofina, Aristeidis Ioannidis, Domniki K. Gerasimidou, Christoforos Efthymiadis, Thomas Zaramboukas
Department of Surgery, Interbalkan Medical Center, Thessaloniki, Greece
Am J Case Rep 2017; 18:830-833
Kaposi sarcoma is a malignancy commonly linked to HIV infection or immunosuppression. An association with human herpes virus 8 (HHV-8) infection has also been reported. We present a case of classic Kaposi sarcoma in a female Mediterranean patient.
CASE REPORT: A 57-year-old white female of Greek ethnicity, with no history of HIV infection or immunosuppression, presented to the Surgical Out-patient Department of our Center, with complaints of extensive discolored skin lesion on both legs, initially considered as chronic vein insufficiency. Histopathological findings from skin biopsies revealed Kaposi sarcoma.
CONCLUSIONS: Non-HIV-related Kaposi sarcoma is an HHV-8-related, angioproliferating skin cancer that can cause pain, disfigurement, and limb dysfunction. High suspicion of this condition can lead to early treatment and delay progression.
Keywords: Immunosuppression, Sarcoma, Kaposi, Skin Abnormalities