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Medical Science Monitor Basic Research


Kaposi Sarcoma in an Human Immunodeficiency Virus (HIV)-Seronegative Mediterranean Female: Report of a Rare Case

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease

Marios Grigoriou, Konstantinia E. Kofina, Aristeidis Ioannidis, Domniki K. Gerasimidou, Christoforos Efthymiadis, Thomas Zaramboukas

Greece Department of Surgery, Interbalkan Medical Center, Thessaloniki, Greece

Am J Case Rep 2017; 18:830-833

DOI: 10.12659/AJCR.903537

Available online:

Published: 2017-07-26


BACKGROUND: Kaposi sarcoma is a malignancy commonly linked to HIV infection or immunosuppression. An association with human herpes virus 8 (HHV-8) infection has also been reported. We present a case of classic Kaposi sarcoma in a female Mediterranean patient.
CASE REPORT: A 57-year-old white female of Greek ethnicity, with no history of HIV infection or immunosuppression, presented to the Surgical Out-patient Department of our Center, with complaints of extensive discolored skin lesion on both legs, initially considered as chronic vein insufficiency. Histopathological findings from skin biopsies revealed Kaposi sarcoma.
CONCLUSIONS: Non-HIV-related Kaposi sarcoma is an HHV-8-related, angioproliferating skin cancer that can cause pain, disfigurement, and limb dysfunction. High suspicion of this condition can lead to early treatment and delay progression.

Keywords: Immunosuppression, Sarcoma, Kaposi, Skin Abnormalities