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Development of Graft-Site Candidiasis in 3 Solid Organ Transplant Recipients from the Same Donor

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Educational Purpose (only if useful for a systematic review or synthesis)

Nasrin El-Bandar, Daniela C. Kroy, Tom Florian Fuller, Jürgen Kramer, Lutz Liefeldt, Klemens Budde, Conrad Blobel, Kurt Miller, Frank Friedersdorff

(Department of Urology, Charité University Hospital Berlin, Berlin, Germany)

Am J Case Rep 2017; 18:777-781

DOI: 10.12659/AJCR.904119

Published: 2017-07-11


BACKGROUND: Graft-site candidiasis rarely develops in solid organ transplant recipients; however, severe life-threatening complications can occur. We report the course of 3 solid organ transplant recipients developing graft-site candidiasis.
CASE REPORT: All grafts, consisting of 2 kidneys and 1 liver, were procured from a single donor. Patient data were collected from our database.
Candida albicans was isolated from a swab taken during multiple-organ recovery. Complications associated with candidiasis occurred in all 3 recipients with preservation of the liver transplant. Both renal transplant recipients had vascular complications, eventually resulting in graft nephrectomy and subsequent return to dialysis. The patients recovered completely without residual effects of their prior fungal infection.
CONCLUSIONS: Fungal infections in solid organ transplant recipients are rare. Since the sequelae of these infections are serious and usually pertain to more than 1 recipient at a time, antifungal prophylaxis may be warranted in select donors.

Keywords: Candida albicans, Lung Diseases, Fungal, Transplantation, Homologous



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