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Medical Science Monitor Basic Research


Takotsubo Myocardiopathy and Hyperthyroidism: A Case Report and Literature Review

Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare co-existance of disease or pathology

Darío Rueda, Rafael Aguirre, Damián Contardo, Paola Finocchietto, Silvia Hernandez, Horacio di Fonzo

Argentina Department of Internal Medicine, Hospital de Clínicas “Jose de San Martin”, University of Buenos Aires, Buenos Aires, Argentina

Am J Case Rep 2017; 18:865-870

DOI: 10.12659/AJCR.905121

Available online: 2017-08-07

Published: 2017-08-07


BACKGROUND: Takotsubo cardiomyopathy (TM), also called stress myocardiopathy or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction with reversible wall motion abnormalities. TM resembles acute coronary syndrome (ACS) in the absence of coronary artery disease (CAD).
In several reports, TM has been described in association with hyperthyroidism, suggesting the potential role of thyrotoxicosis in the pathophysiology.
CASE REPORT: We present the case of a 34-year-old man with TM associated with hyperthyroidism caused by Graves’ disease. In this case, TM was also preceded by an emotional trigger.
The diagnosis of TM was based on clinical manifestations, electrocardiographic and echocardiographic abnormalities, and the absence of coronary artery disease (CAD) in the angiography. A diagnosis of hyperthyroidism was made based on hormonal and antibody measurements. The patient had a favorable outcome, and the cardiac and thyroid disorders resolved.
CONCLUSIONS: Our case illustrates that thyroid disease, mainly hyperthyroidism, should be considered in patients with TM with or without previous emotional triggers. As in our patient, the outcome in TM is usually favorable, with reversibility of cardiac abnormalities.

Keywords: Cardiomyopathies, hyperthyroidism, takotsubo cardiomyopathy, Thyroid Diseases