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Medical Science Monitor Basic Research


Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature

Unusual clinical course, Unusual or unexpected effect of treatment

Yvette Farran, Osvaldo Padilla, Karinn Chambers, Alexander Philipovskiy, Zeina Nahleh

USA Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA

Am J Case Rep 2017; 18:1347-1350

DOI: 10.12659/AJCR.905157

Available online: 2017-12-18

Published: 2017-12-18


BACKGROUND: Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence.
CASE REPORT: Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences.
CONCLUSIONS: The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.

Keywords: Heavy Ion Radiotherapy, Hemangiosarcoma, Mastectomy