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Medical Science Monitor Basic Research


Bone Marrow Mononuclear Cells Transplantation in Treatment of Established Bronchopulmonary Dysplasia: A Case Report

Management of emergency care

Nguyen Thanh Liem, Tran Lien Anh, Trieu T. Hong Thai, Bui Viet Anh

Vietnam Department of Stem Cell and Immune Cell, inmec Research Institute of Stem Cells and Gene Technology, Hanoi, Vietnam

Am J Case Rep 2017; 18:1090-1094

DOI: 10.12659/AJCR.905244

Available online:

Published: 2017-10-12


BACKGROUND: Bronchopulmonary dysplasia (BDP) is an incurable disease. This study reports the successful treatment of a 30-week-old neonate with established bronchopulmonary dysplasia by bone marrow mononuclear cells (BM MNCs) transplantation.
CASE REPORT: The preterm infant with BPD requiring continuous oxygen administration for 4 months post-delivery underwent BM MNCs. Bone marrow was obtained from the patient’s iliac crests and mononuclear cells were isolated by density gradient centrifugation method. BM MNCs were delivered via endotracheal and intravenous routes. After BM MNCs transplantation, remarkable improvements were observed in oxygen saturation and lung CT as the infant was gradually weaned off oxygen supply.
CONCLUSIONS: BM MNCs transplantation offers promising treatment of BPD.

Keywords: Bone Marrow Cells, Bronchopulmonary Dysplasia, Stem Cell Transplantation