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Medical Science Monitor Basic Research


Asymptomatic Meningitis and Lung Cavity in a Case of Cryptococcosis

Challenging differential diagnosis, Rare co-existance of disease or pathology

Aixin Li, Qunhui Li, Caiping Guo, Yulin Zhang

China (mainland) Department of Infectious Diseases, Capital Medical University Affiliated Beijing You An Hospital, Beijing Institute of Hepatology, Beijing, China (mainland)

Am J Case Rep 2017; 18:1140-1144

DOI: 10.12659/AJCR.905905

Available online:

Published: 2017-10-26


BACKGROUND: Cryptococcus neoformans (C. neoformans) infection is one of the most common opportunistic infections in AIDS patients. C. neoformans usually infects the central nervous system (CNS) and/or lungs with typical clinical manifestation.
CASE REPORT: Here, we report the case of a 52-year-old HIV-1-infected man with disseminated cryptococcosis, including subacute meningitis, pulmonary, and cutaneous cryptococcosis, but only skin lesion served as the chief complaint. Moreover, the results of cerebrospinal fluid (CSF) tests and lung computed tomography (CT) scan were atypical.
CONCLUSIONS: We present the clinical characteristics of this case and discuss the diagnostic procedure, which will likely help clinicians in making a timely definitive diagnosis of this disease.

Keywords: case reports, Cryptococcosis, Cryptococcus neoformans