08 November 2017 : Case report
Successful Treatment of Severe Tardive Dyskinesia with Valbenazine, Including a Patient’s Perspective
Unusual clinical course, Challenging differential diagnosisRichard C. Josiassen1ADE*, Dawn M. Filmyer2ABDE, Jack Gillean34BC, Syed Sikandar Shah45BC, Tyler E. Dietterich2F, Rita A. Shaughnessy24ABDE
Am J Case Rep 2017; 18:1185-1189
BACKGROUND: Tardive dyskinesia (TD) is a chronic involuntary movement disorder frequently induced by dopamine receptor blockers, particularly first-generation antipsychotics. Until recently, management of TD was restricted to lowering the dose of the current medication, switching to another medication, or using off-label treatments with insufficient evidence of efficacy. Valbenazine, a vesicular monoamine transporter-2 (VMAT2) inhibitor, became the first drug to be approved by the FDA specifically for the treatment of TD.
CASE REPORT: We describe the case of a 49-year-old African-American woman who was diagnosed with bipolar disorder at the age of 34 and treated with lithium carbonate (900 mg daily) and citalopram (10 mg daily). She also received low doses of second-generation antipsychotics for weeks at a time, but these were always discontinued due to severe sedation. Over a decade later, at the age of 45, she experienced rapid onset of severe TD symptoms. She enrolled in a phase III double-blind clinical trial and received valbenazine 80 mg, with encouraging results.
CONCLUSIONS: Once-daily dosing of valbenazine (80 mg) was effective and safe over a long period, even in this atypical case of severe and rapid-onset TD.
Keywords: Movement Disorders, Vesicular Monoamine Transport Proteins
13 May 2022 : Case reportAcute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination
Am J Case Rep In Press; DOI: 10.12659/AJCR.936574
20 April 2022 : Case reportProgressive Worsening of Neurological Manifestations in HIV-Associated Opportunistic Central Nervous System...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936257
16 May 2022 : Case reportPrimary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level of Consciousne...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936401
16 May 2022 : Case reportLong-Term Efficacy of Dupilumab in Alopecia Areata
Am J Case Rep In Press; DOI: 10.12659/AJCR.936488
16 May 2022 : Case reportStellate Hypopigmentation in a Pediatric Patient After Treatment with Intralesionally-Injected Corticosteroid
Am J Case Rep In Press; DOI: 10.12659/AJCR.935898
Most Viewed Current Articles
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case reportMyocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...
Am J Case Rep 2022; 23:e934399
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406