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21 February 2018 : Case report  Italy

Severe Fetal Distress and Placental Damage might be Associated with High Troponin I (cTnI) Levels in Mothers

Unknown etiology, Challenging differential diagnosis

Irene Turrini1AE*, Flavia Sorbi1EF, Viola Ghizzoni1E, Luca Mannini1E, Massimiliano Fambrini1D, Alessandro Terreni2D, Elisabetta Projetto3B, Francesca Castiglione2B, Ivo Noci1DE

DOI: 10.12659/AJCR.906617

Am J Case Rep 2018; 19:194-198

Abstract

BACKGROUND: Troponin I is the gold standard for the diagnosis of adult acute coronary syndrome. Although it is known that a hypoxic fetus may produce cTnI, fetal cTnI passage in maternal blood has never been documented.

CASE REPORT: We report a case where the rise of cTnI in the blood of a pregnant woman was not related to maternal heart disease. Instead, it might be suggestive of a fetal cardiac origin, as there was a severe placental insufficiency with a fetal intrauterine growth restriction.

CONCLUSIONS: This study suggests that the rise of cTnI in maternal blood in a cardiovascular healthy pregnant woman might have a fetal origin. After having excluded any maternal causes, cTnI elevation could be explained with the transfer of fetal cTnI through an injured placenta.

Keywords: Fetal Growth Retardation, Fetal Hypoxia, Placenta Diseases, troponin I

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923