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Medical Science Monitor Basic Research


Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease

Challenging differential diagnosis, Rare disease

Swati Prabhakar, Ahmad M. Tuffaha

USA Department of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, KS, USA

Am J Case Rep 2018; 19:118-122

DOI: 10.12659/AJCR.906981

Available online: 2018-02-01

Published: 2018-02-01


BACKGROUND: Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function.
CASE REPORT: We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. She was treated with sodium thiosulfate along with wound care and hyperbaric oxygen with complete resolution of the lesions, but with residual scarring.
CONCLUSIONS: Non uremic calciphylaxis is a rare phenomenon that is poorly understood. It should be in the differential of unexplained skin lesions even in the absence of renal insufficiency. Sodium thiosulfate plays a role in treatment, but wound care remains the main focus of treatment.

Keywords: calciphylaxis, Sodium Thiosulfate, Hyperbaric Oxygenation