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24 April 2018 : Case report  USA

Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus

Unknown etiology

Roger A. Fecher1ADEF, Brittany A. Leader2EF, Yash Patil2AE, Randall Butler3ADE*

DOI: 10.12659/AJCR.908252

Am J Case Rep 2018; 19:482-485

Abstract

BACKGROUND: Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5–5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma.

CASE REPORT: Here, we present a case of tonsillar SmCC that presented as combined SmCC-squamous cell carcinoma in a cervical lymph node, raising the possibility that the SmCC-component represents disease progression.

CONCLUSIONS: This case lends further support to the importance of HPV in the development of oropharyngeal SmCC and suggests a mechanism of disease progression.

Keywords: Carcinoma, Small Cell, Disease Progression, Papillomavirus Infections

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923