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27 March 2018 : Case report  Japan

Resolution of Infliximab-Refractory Nivolumab-Induced Acute Severe Enterocolitis After Cyclosporine Treatment in a Patient with Non-Small Cell Lung Cancer

Adverse events of drug therapy

Tomokazu Iyoda1ABCDEF, Noriaki Kurita23ADEF*, Ayumi Takada1BC, Hiroe Watanabe1BC, Masahiro Ando4BCDF

DOI: 10.12659/AJCR.908570

Am J Case Rep 2018; 19:360-364

Abstract

BACKGROUND: Enterocolitis is an immune-related adverse event associated with nivolumab treatment. Although intravenous corticosteroids and infliximab are recommended as a first-line and second-line therapy, respectively, there is no established treatment for severe enterocolitis that is refractory to these drugs.

CASE REPORT: A 62-year-old male with non-small cell lung cancer, with multiple brain metastasis, received nivolumab as the eighth-line chemotherapy for his disease. A few days after nivolumab administration, grade 2–3 enterocolitis developed in the patient. The enterocolitis improved to grade 1 after careful observation; however, it was aggravated to grade 3 after resuming nivolumab treatment. After cessation of nivolumab, 3.3 mg of intravenous dexamethasone and 40 mg of methylprednisolone were administered for 16 days and subsequently 30–60 mg of oral prednisolone was administered for 50 days, with little improvement in the patient’s colitis. A second-line treatment with 5 mg/kg of infliximab was twice attempted, but the patient had persistent diarrhea. Therefore, 50 mg of oral cyclosporine was started as a third-line therapy. Three days after the start of cyclosporine, the number of diarrhea events decreased, with resolution 2 weeks after cyclosporine administration.

CONCLUSIONS: Oral cyclosporine treatment can be a third-line therapy for enterocolitis associated with immune-related adverse events.

Keywords: Cyclosporine, Drug-Related Side Effects and Adverse Reactions, Enterocolitis

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923