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Medical Science Monitor Basic Research


A Fatal Case of Non-Uremic Calciphylaxis: A Case Report and Literature Review

Rare disease

Abubaker O. Abdalla, Jaafar Al-Khafaji, Mohamed Taha, Samira Malik

USA Department of Internal Medicine, School of Medicine, University of Nevada, Reno, NV, USA

Am J Case Rep 2018; 19:804-807

DOI: 10.12659/AJCR.909546

Available online: 2018-07-09

Published: 2018-07-09


BACKGROUND: Calciphylaxis is a rare cutaneous disease, also known as calcific uremic arteriolopathy, that occurs most frequently in patients with advanced chronic kidney disease and on long-term hemodialysis.
CASE REPORT: We describe the case of a 61-year-old female patient with worsening chronic kidney disease not on dialysis therapy, who presented with severe progressive calciphylaxis on both lower limbs.
CONCLUSIONS: Calcific uremic arteriolopathy is a rare fatal condition that requires prompt diagnosis and treatment. It is classically described in patients with end-stage kidney disease on long-term renal replacement therapy but can present in patients with an earlier stage of kidney disease. Non-uremic calciphylaxis should be suspected in patients with earlier stages of kidney disease, especially in those with other concurrent risk factors or co-morbid conditions, to avoid the high risk of morbidity and mortality associated with such cases.

Keywords: calciphylaxis, Renal Insufficiency, Chronic, vascular calcification