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Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases

Congenital defects / diseases

Nguyen Thanh Liem, Vu Duy Chinh, Nguyen Thi Thinh, Ngo Duy Minh, Hoang Minh Duc

Stem Cell and Immune Cell Department, Vinmec Research Institute of Stem Cell and Gene Technology, Times City, Ha Noi, Vietnam

Am J Case Rep 2018; 19:1010-1018

DOI: 10.12659/AJCR.909801

Available online:

Published: 2018-08-25

BACKGROUND: Bowel dysfunction is observed in 42.2–71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation.
CASE REPORT: Two patients – 14 years old and 11 years old – with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively.
CONCLUSIONS: BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.

Keywords: adult stem cells, Bone Marrow Transplantation, Spina Bifida Occulta