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Medical Science Monitor Basic Research


Rhabdomyolysis with Peripheral Neuropathy: A Case Series and Literature Review

Unusual clinical course

Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Kang Min Park, Il Hwan Kim, Jin Han Park, Byeong Ju Lee, Bong Soo Park

South Korea Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea

Am J Case Rep 2018; 19:1272-1278

DOI: 10.12659/AJCR.911602

Available online:

Published: 2018-10-26


BACKGROUND: Rhabdomyolysis is a syndrome characterized by muscle necrosis and secretion of intracellular muscle components into the blood circulation. Acute compartment syndrome is a potential complication of severe rhabdomyolysis.
CASE REPORT: We report 3 cases of compartment syndrome-related peripheral neuropathy in alcoholic individuals with rhabdomyolysis. All patients were confirmed to have peripheral neuropathy by electrophysiologic studies.
CONCLUSIONS: Patients with underlying metabolic abnormalities, such as those related to long-term alcoholism, should be aware that rhabdomyolysis is likely to cause neurological abnormalities.

Keywords: Compartment Syndromes, Peripheral Nervous System Diseases, rhabdomyolysis