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A Case of Pregnancy Complicated by Primary Hyperparathyroidism Due to a Parathyroid Adenoma

Mistake in diagnosis, Rare co-existance of disease or pathology

Natalia G. Mokrysheva, Anna K. Eremkina, Svetlana S. Mirnaya, Lyudmila Y. Rozhinskaya, Nikolay S. Kuznetsov, Rosa M. Yesayan, Natalia E. Kan, Ekaterina N. Dudinskaya

(Department of Parathyroid Gland Pathology, Endocrinology Research Center, The Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation)

Am J Case Rep 2019; 20:53-59

DOI: 10.12659/AJCR.912436

Published: 2019-01-14


BACKGROUND: Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate.
CASE REPORT: During her second pregnancy, a 28-year-old woman presented with symptoms of general weakness, bone and joint pain, multiple fractures with bone deformity, muscle weakness, and gait disturbance. Due to the high risk of perinatal pathology, a cesarean section was performed. Several weeks later, she underwent thoracoscopic removal of an ectopic parathyroid gland located at the aortic arch. Hypocalcemia in the newborn infant required treatment with calcium and magnesium supplements.
CONCLUSIONS: This case demonstrates that primary hyperparathyroidism during pregnancy requires timely diagnosis and treatment to reduce potential maternal and fetal complications. Screening for primary hyperparathyroidism should be undertaken in pregnant women with any symptoms associated with hypercalcemia. Treatment should be individualized and includes conservative management, parathyroidectomy in the second trimester, or parathyroidectomy performed in the early postpartum period.

Keywords: Hypercalcemia, Hyperparathyroidism, Primary, Osteoporosis, Parathyroid Hormone, Pregnancy



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