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Biventricular Pacing Going Along with Acute Hemodynamic Response in a Patient with Huge Anterior Wall Aneurysm – Importance of Pacing Viable Myocardium

Unusual clinical course, Unusual or unexpected effect of treatment

Spyridon Liosis, Evgeny Lyan, Amr Abdin, Ben Brüggemann, Stefan A. Lange, Julia Vogler, Christian H. Heeger, Kivanc Yalin, Roland R. Tilz, Charlotte Eitel

Department of Cardiology, University Heart Center Lübeck, Lübeck, Germany

Am J Case Rep 2019; 20:810-815

DOI: 10.12659/AJCR.914480

Available online:

Published: 2019-06-09

BACKGROUND: Response to cardiac resynchronization therapy (CRT) is variable among patients. Extensive scar tissue burden has been characterized as a negative predictor of significant response. Whereas mid-term and long-term response has been thoroughly investigated in randomized clinical trials; however, little is known about acute hemodynamic effects of biventricular pacing.
CASE REPORT: We report a case of an elderly female patient with severe ischemic cardiomyopathy and a large anterior wall aneurysm, who received right ventricular and biventricular pacing during ablation of incessant pleomorphic ventricular tachycardia. During the procedure, biventricular pacing was associated with a 20% acute increase in systolic blood pressure compared to right ventricular pacing, although there was no acute or long-term effect on left ventricular function.
CONCLUSIONS: The acute hemodynamic effect of CRT in our patient suggests an effect of CRT even in patients with negative predictors of CRT response such as severe ischemic cardiomyopathy with a large aneurysm. Although no marked increase in left ventricular function might be observed, the acute effect of CRT might contribute to stabilization of heart failure in these patients.

Keywords: cardiac resynchronization therapy, Heart Aneurysm