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Medical Science Monitor Basic Research


Glassy Cell Carcinoma of the Endometrium Presenting as an Intracavitary Leiomyoma on Ultrasound

Mistake in diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Courtney Fox, Veronica Schimp, Li Ge, Yehuda Galili, Steve J. Carlan

USA Department of Obstetrics and Gynecology, Orlando Regional Healthcare, Orlando, FL, USA

Am J Case Rep 2019; 20:961-964

DOI: 10.12659/AJCR.915809

Available online: 2019-07-05

Published: 2019-07-05


BACKGROUND: Glassy cell carcinoma of the endometrium is an extremely rare variant of adenosquamous carcinoma, and it has a poor prognosis. In postmenopausal women it typically presents as unprovoked, painless uterine bleeding. Tissue sampling is necessary to establish the diagnosis.
CASE REPORT: A 58-year-old postmenopausal woman on no hormone replacement therapy experienced 2 months of intermittent uterine bleeding. An office transvaginal ultrasound discovered a 1.7-cm intracavitary leiomyoma, but because the endometrial stripe was not visualized, an endometrial biopsy was performed. She was found to have a Stage 1 A endometrial poorly-differentiated adenosquamous carcinoma, glassy cell carcinoma tumor of 1.5 cm in greatest dimension. She underwent a robotic total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph node mapping, and bilateral pelvic lymphadenectomy.
CONCLUSIONS: Glassy cell carcinoma of the endometrium can present as an intracavitary leiomyoma in postmenopausal women.

Keywords: Carcinoma, Adenosquamous, Endometrial Neoplasms, Leiomyoma