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Medical Science Monitor Basic Research


Chronic Cavitary Pulmonary Aspergillosis: A Case Report and Review of the Literature

Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Educational Purpose (only if useful for a systematic review or synthesis)

Kathryn G. Graham, Asad Nasir

USA Arnot Ogden Medical Center Residency Program, Arnot Health, Elmira, NY, USA

Am J Case Rep 2019; 20:1220-1224

DOI: 10.12659/AJCR.915893

Available online: 2019-08-18

Published: 2019-08-18


BACKGROUND: Aspergillus spores have the ability to affect patients with or without intact immune systems; because of this disease’s wide patient involvement it deserves a place on the differential diagnosis list, with endocarditis and tuberculosis, for those presenting with new pulmonary nodules or cavitation.
CASE REPORT: This case report involves the presentation, diagnosis, and treatment of a 69-year-old female who presented with new rapidly progressing cavitary lung lesions in the setting of copious administration of systemic steroid use. Given the patient’s past history of alcoholism and environmental exposure, her case was not straight forward in regard to a diagnosis. Ultimately, she was diagnosed with chronic cavity pulmonary aspergillosis in the setting of chronic immunosuppression secondary to systemic steroid administration. Due to her convoluted medical history and the poor differential diagnosis list, there was a delay in final diagnosis.
CONCLUSIONS: This case report and clinical review aims to prevent anchoring when the patient’s presentation is not straight forward and aims to remind the clinician of the importance of a differential diagnosis.

Keywords: Aspergillosis, Allergic Bronchopulmonary, invasive pulmonary aspergillosis, Pulmonary Disease, Chronic Obstructive