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Medical Science Monitor Basic Research


Calcineurin Inhibitors and Neutropenia: Is Cyclosporine Superior to Tacrolimus?

Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)

Tanu Duggal, Meghan Dempster, Rohini Prashar

USA Department of Medicine, Lawrence General Hospital, Lawrence, MA, USA

Am J Case Rep 2019; 20:1407-1410

DOI: 10.12659/AJCR.917282

Available online:

Published: 2019-09-24


BACKGROUND: Renal Transplant recipients are at risk for developing neutropenia from a multitude of causes. The cause is often multifactorial, and reversal of the most common causes/insults is sometimes insufficient.
CASE REPORT: We present the case of a renal transplant recipient who developed a prolonged course of post-transplant (PTx) neutropenia that resolved after switching from tacrolimus (tac) to cyclosporine (CsA).
CONCLUSIONS: Transplant recipients with persistent neutropenia, sometimes despite discontinuation of potential myelosuppressive agents like mycophenolic acid (MPA), valganciclovir, and sulfamethoxazole-trimethoprim (SMZ-TMP), and with introduction of granulocyte colony-stimulating factor (G-SF), and ruling out alternative diagnoses, may benefit from changing from tac to CsA.

Keywords: Cyclosporine, Kidney Transplantation, Neutropenia, Tacrolimus