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Medical Science Monitor Basic Research


Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report

Unusual clinical course, Mistake in diagnosis

Inessa Dombrovsky, Hannah R. Tilden, Tania Aftandilians, Shirley Wong, Robert J. Stowe

USA Department of Women’s Health, Arrowhead Regional Medical Center, Colton, CA, USA

Am J Case Rep 2020; 21:e917656

DOI: 10.12659/AJCR.917656

Available online: 2020-01-24

Published: 2020-01-27


BACKGROUND: Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal choriocarcinoma is exceptionally rare and few cases have been described in the literature.
CASE REPORT: We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up.
CONCLUSIONS: Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy.

Keywords: Choriocarcinoma, Neoplasm Metastasis, Postmenopause