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Concurrent Adrenal and Extra-Adrenal Ganglioneuromas: A Case Report

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Educational Purpose (only if useful for a systematic review or synthesis)

Maram Hussein AlGhamdi, Abdullah AlAyed, Nayef A. AlShabyli, Nour Hussain AlGhamdi, Mohannad AlRasheed

Department of Radiology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

Am J Case Rep 2019; 20:1817-1820

DOI: 10.12659/AJCR.918568

Available online:

Published: 2019-12-06


BACKGROUND: Ganglioneuroma is a rare benign sympathetic chain neoplasm which rarely arise from the adrenal gland in adults and exceedingly rare for ganglioneuroma to arise from different origins in the same patient. We present a rare case of retroperitoneal ganglioneuroma concurring with an adrenal ganglioneuroma in an adult patient.
CASE REPORT: A 17-year-old healthy male underwent computed tomography (CT) scan after road traffic accident where he was found to have a left adrenal homogeneous hypovascular lesion with another retroperitoneal lesion seen within the right para-colic gutter with similar radiological features. Successful surgical resection was obtained, and histological diagnosis of both lesions was benign ganglioneuroma.
CONCLUSIONS: Adrenal and extra-adrenal ganglioneuroma can, although rare, concur together. Key findings are the similar radiological appearance of the lesions with typical hypovascular progressive pattern of enhancement. Appropriate pre-surgical diagnosis can aid to proper management since ganglioneuroma needs wide surgical resection due to its high chance of recurrence.

Keywords: Adrenal Glands, Ganglioneuroblastoma, Ganglioneuroma



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