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Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease

Hussein A. Abbas, Behrang Amini, Wei-Lien Wang, Vinod Ravi

USA Division of Cancer Medicine, Hematology-Oncology Fellowship Program, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Am J Case Rep 2020; 21:e918878

DOI: 10.12659/AJCR.918878

Available online: 2020-02-10

Published: 2020-03-21


#918878

BACKGROUND: Primary cardiac tumors are rare and mostly benign. Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months. The diagnosis of cardiac sarcomas may be challenging. Treatment entails surgical resection despite the high rate of recurrence, as well as adjuvant chemotherapy.
CASE REPORT: In this report, we discuss a case of a 58-year-old male with undifferentiated pleomorphic primary cardiac sarcomas who received multiple lines of treatment that included surgery, chemotherapy, and targeted therapy and was alive more than 4 years after his diagnosis. Herein, we discuss the different treatment regimens utilized and we present detailed imaging of his case findings at different treatment stages.
CONCLUSIONS: Treatment of undifferentiated pleomorphic cardiac sarcoma requires a multidisciplinary approach. Surgery and adjuvant treatment are commonly utilized, while neoadjuvant treatment is under investigation.

Keywords: Cardiac Surgical Procedures, Chemoradiotherapy, Adjuvant, Sarcoma



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