26 January 2020 : Case report
Fulminant and Diffuse Cerebral Toxoplasmosis as the First Manifestation of HIV Infection: A Case Presentation and Review of the Literature
Unusual clinical course, Challenging differential diagnosisSalman Abbasi Fard1AE*, Ali Khajeh2B, Alireza Khosravi3B, Afsaneh Mirshekar2B, Safoora Masoumi2B, Farhad Tabasi4EF, Tania Hassanzadeh1F, Martin M. Mortazavi1F
Am J Case Rep 2020; 21:e919624
BACKGROUND: One of the most common causes of central nervous system (CNS) opportunistic infections in immunocompromised patients is toxoplasmosis. It can cause focal or disseminated brain lesions leading to neurological deficit, coma, and death. Prompt management with optimal antibiotics is vital. However, the diagnosis of cerebral toxoplasmosis is challenging in infected individuals with human immunodeficiency virus (HIV). The possible diagnosis is based on clinical presentation, imaging, and specific serologic investigations. The diagnosis can be confirmed by histopathological examination and/or by finding nucleic material in the spinal cerebrospinal fluid (CSF) examination.
CASE REPORT: We present a review of the literature with a rare illustrative case of diffuse CNS toxoplasmosis as the first manifestation of HIV infection in a young patient. Brain MRI showed diffuse, ring-enhancing lesions, and significant midline shift. Decompressive hemicraniectomy for control of intracranial pressure and anti-infectious therapy were performed.
CONCLUSIONS: This should raise awareness that cerebral toxoplasmosis can occur in pediatric patients with HIV infection, and, more importantly, as the first manifestation of AIDS. Although the prognosis is often poor, early diagnosis and immediate treatment of this life-threatening opportunistic infection can improve outcomes.
Keywords: HIV Infections, Neurosurgery, Toxoplasmosis, Cerebral, AIDS-Related Opportunistic Infections, Child, Fatal Outcome, Magnetic Resonance Imaging, Male
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