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Multifocal Thrombophlebitis and Orbital Cellulitis

Challenging differential diagnosis, Rare co-existance of disease or pathology

Alojzija Hočevar, Daša Šuput Skvarča, Matija Tomšič, Katja Perdan Pirkmajer

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia

Am J Case Rep 2020; 21:e919715

DOI: 10.12659/AJCR.919715

Available online:

Published: 2020-01-14

BACKGROUND: Multifocal superficial thrombophlebitis is a rare clinical manifestation with wide differential diagnosis in relation to the background disease.
CASE REPORT: Here we report on 2 patients who presented with a systemic inflammatory response, multifocal thrombophlebitis, and orbital inflammation in whom a diagnosis of a defined background disease could not be established.
CONCLUSIONS: The clinical pattern of our 2 cases might represent a distinctive, not yet defined systemic medical condition.

Keywords: Inflammation, orbital cellulitis, Thrombophlebitis