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Medical Science Monitor Basic Research


Clinical Management of Squamous Cell Carcinoma of the Conjunctiva

Challenging differential diagnosis, Management of emergency care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Tobias Röck, Karl Ulrich Bartz-Schmidt, Matthias Bramkamp, Jakob Milla, Hans-Christian Bösmüller, Daniel Röck

Germany Department of Ophthalmology, Eberhard Karls University Tübingen, Tübingen, Germany

Am J Case Rep 2020; 21:e919751

DOI: 10.12659/AJCR.919751

Available online: 2020-01-24

Published: 2020-02-01


BACKGROUND: Conjunctival squamous cell carcinoma is the most common non-pigmented malignancy of the ocular surface. This report illustrates the clinical management of squamous cell carcinoma of the conjunctiva.
CASE REPORT: A 33-year-old female was referred to our eye hospital with a tumorous lesion on the nasal bulbar conjunctiva of the right eye. A topical therapy with antibiotic and corticosteroid eye drops did not change the lesion. The conjunctival tumor was widely resected. The histopathological diagnosis suggested a squamous cell carcinoma. After resection, a treatment with topical mitomycin C (MMC) 0.02% eye drops were started 4 times daily for 14 days. Two cycles of treatment were done with a 2-week interval during which only artificial tears eye drops were administered. At the 12-month follow-up, there was no sign of recurrence.
CONCLUSIONS: This case illustrates the effective and successful clinical management of squamous cell carcinoma of the conjunctiva with excision and postoperative treatment with MMC 0.02% eye drops.

Keywords: Ambulatory Surgical Procedures, Carcinoma, Squamous Cell