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Medical Science Monitor Basic Research


A Case Report from the Ancient Past

Educational Purpose (only if useful for a systematic review or synthesis)

William H. Adams

USA Retired, Hobart, NY, USA

Am J Case Rep 2019; 20:1907-1914

DOI: 10.12659/AJCR.919830

Available online:

Published: 2019-12-20

BACKGROUND: Standard translations of Hippocratic works are sometimes misleading because the translators knew less about their subject than did the ancient authors.
CASE REPORT: A new translation and explication of a chapter from a Hippocratic work of the fifth century before the Common Era (BCE), Diseases II, describes patients with pituitary apoplexy and subsequent myxedema, the 2 events separated by as much as 14 years.
CONCLUSIONS: The association of myxedema with an intracranial event that occurred years earlier predates by 2400 years the causal association of a pituitary adenoma with hormonal deficiency.

Keywords: Hippocrates, History, Ancient, Myxedema, pituitary apoplexy