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Medical Science Monitor Basic Research


Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: An Uncommon Finding in an Uncommon Patient

Unknown etiology

Alessandra Surace, Viola Liberale, Marta D’Alonzo, Silvia Pecchio, Maria Grazia Baù, Nicoletta Biglia

Italy Department of Obstetrics and Gynecology, AOU City of Health and Science, University of Turin, Turin, Italy

Am J Case Rep 2020; 21:e919856

DOI: 10.12659/AJCR.919856

Available online: 2020-01-16

Published: 2020-01-16


BACKGROUND: Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast lesion.
CASE REPORT: PASH is reported in a young female in treatment for neurological diseases with multi-drug therapy (clonazepam, valproate and risperidone). Her menstrual cycles are irregular, and she reached menarche very late.
CONCLUSIONS: The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in 24% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate, risperidone and progesterone could increase the level of progesterone that could stimulate PASH growth.

Keywords: Breast Diseases, Drug Therapy, Combination, Mastectomy, Segmental