Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

23 June 2020 : Case report  Spain

A Case of Paraneoplastic Cerebellar Degeneration that Preceded the Diagnosis of Classical Hodgkin’s Lymphoma by 16 Months

Unknown etiology, Challenging differential diagnosis

Nerea Arratibel1ABDEF, Eduardo Sobejano1EF, Jose Carlos Moran2BD, Luis G. Diaz3BD, Almudena Blázquez4BD, Mónica Baile1BD, Álvaro Veiga1BD, Maria Dolores Caballero1BD, Ramón García-Sanz1ABDEF*

DOI: 10.12659/AJCR.922342

Am J Case Rep 2020; 21:e922342

Abstract

BACKGROUND: Paraneoplastic cerebellar degeneration (PCD) is a rare condition that can present as an acute or subacute cerebellar syndrome. PCD is most commonly associated with gynecological and breast cancer, small-cell lung cancer, and classical Hodgkin’s lymphoma. The symptoms of PCD can arise several months before tumor diagnosis. This report is of a case of a 44-year-old man with PCD that preceded the diagnosis of classical Hodgkin’s lymphoma by 16 months.

CASE REPORT: A 44-year-old man was admitted to hospital with a cerebellar syndrome that was initially diagnosed as vertebrobasilar insufficiency. Eight months later, cerebral magnetic resonance imaging (MRI) findings and serum anti-Tr antibodies supported the diagnosis of PCD, but no underlying malignancy was initially found. At 16 months after the initial diagnosis of PCD, the patient developed an enlarged inguinal lymph node. Histology of the excisional lymph node biopsy confirmed the diagnosis of classic mixed cellularity Hodgkin’s lymphoma, Ann Arbor stage IIA. The patient responded to four cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy.

CONCLUSIONS: This case illustrates that in patients who present with PCD, an associated malignancy, such as classical Hodgkin’s lymphoma, may emerge several months later, which supports long-term follow-up. The presence of anti-Tr antibodies may support a diagnosis of classical Hodgkin’s lymphoma in a patient with a history of PCD who develops lymphadenopathy.

Keywords: Hodgkin Disease, Neurologic Manifestations, Paraneoplastic Cerebellar Degeneration

0 Comments

SARS-CoV-2/COVID-19

08 December 2021 : Case report  Poland

A 63-Year-Old Man with a Diagnosis of Re-Infection with SARS-CoV-2 Nine Weeks After an Initial Hospital Adm...

Am J Case Rep In Press; DOI: 10.12659/AJCR.932999  

01 December 2021 : Case report  USA

A 48-Year-Old Immunocompetent Female Resident of Southern Florida with Confirmed Reinfection with P.1 (Gamm...

Am J Case Rep In Press; DOI: 10.12659/AJCR.935329  

26 November 2021 : Case report  Poland

Arteritic Anterior Ischemic Optic Neuropathy in the Course of Giant Cell Arteritis After COVID-19

Am J Case Rep In Press; DOI: 10.12659/AJCR.933471  

01 December 2021 : Case report  USA

Progressive Pulmonary Fibrosis After Non-Critical COVID-19: A Case Report

Am J Case Rep 2021; 22:e933458

In Press

08 Dec 2021 : Case report  Poland

A 63-Year-Old Man with a Diagnosis of Re-Infection with SARS-CoV-2 Nine Weeks After an Initial Hospital Adm...

Am J Case Rep In Press; DOI: 10.12659/AJCR.932999  

08 Dec 2021 : Case report  USA

Prolonged Cefepime-Induced Neurotoxicity in a Patient with End-Stage Renal Disease

Am J Case Rep In Press; DOI: 10.12659/AJCR.934083  

07 Dec 2021 : Case report  Greece

Combination of Adenomyoepithelioma and Adenoid Cystic Carcinoma of the Breast: A Case Report of an Uncommon...

Am J Case Rep In Press; DOI: 10.12659/AJCR.934391  

07 Dec 2021 : Case report  Germany

A Rare Cause of Left Shoulder Pain in a Peritoneal Dialysis Patient

Am J Case Rep In Press; DOI: 10.12659/AJCR.933223  

Most Viewed Current Articles

15 Aug 2020 : Case report  USA

A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodul...

DOI :10.12659/AJCR.926779

Am J Case Rep 2020; 21:e926779

09 May 2019 : Case report  USA

A Rare Case of Stage IV Basaloid Squamous Cell Cancer with Intrapulmonary and Brain Metastases

DOI :10.12659/AJCR.915073

Am J Case Rep 2019; 20:664-667

13 Mar 2019 : Case report  USA

Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke’s Encephalopathy...

DOI :10.12659/AJCR.914051

Am J Case Rep 2019; 20:330-334

09 Jan 2019 : Case report  Saudi Arabia

3-M Syndrome: A Local Case Report

DOI :10.12659/AJCR.912736

Am J Case Rep 2019; 20:36-38

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923