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Medical Science Monitor Basic Research


Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion

Challenging differential diagnosis

Hala A. Helmi, Waleed Alsarhani, Hind Manaa Alkatan, Ammar C. Al-Rikabi, Yasser H. Al-Faky

Saudi Arabia College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

Am J Case Rep 2020; 21:e925134

DOI: 10.12659/AJCR.925134

Available online: 2020-06-26

Published: 2020-08-13


BACKGROUND: Sebaceous gland carcinoma (SGC) is a rare malignant lesion that occurs on the eyelids. It is known to mimic other benign or malignant lesions in clinical presentation, such as a chalazion, basal cell carcinoma, and squamous cell carcinoma. The histopathological diagnosis is the mainstay for diagnosis and is often challenging.
CASE REPORT: We describe a case of SGC in a 53-year-old woman who presented with a cauliflower-appearing lesion with pearly telangiectatic vessels and raised margins at the lower eyelid margin. Clinically, we suspected a diagnosis of basal cell carcinoma. Upon complete resection of the lesion, the final diagnosis was SGC based on the histopathological features and immunohistochemical staining characteristics of the tissue.
CONCLUSIONS: Due to the possibility of SGC presenting similarly to other lesions, it is essential for ophthalmologists to have a high index of suspicion in its diagnosis. The early and accurate diagnosis of such lesions is important for appropriate management to prevent metastasis or recurrence related to advanced tumors.

Keywords: Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Immunohistochemistry, Pathology, Sebaceous Gland Neoplasms