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Medical Science Monitor Basic Research


Rat Bite Fever: The First Case Report from Qatar

Rare disease

Mohamad Y. Khatib, Moustafa S. Elshafei, Dnyaneshwar P. Mutkule, Amr M. Shabana, Dinesh Chengamaraju, Abdulqadir J. Nashwan

Qatar Department of Critical Care, Hazm Mebaireek General Hospital (HMGH), Hamad Medical Corporation (HMC), Doha, Qatar

Am J Case Rep 2020; 21:e925647

DOI: 10.12659/AJCR.925647

Available online: 2020-08-28

Published: 2020-10-10


BACKGROUND: Rat bite fever (RBF) is a rare but fatal zoonotic disease caused by infections with various bacteria, which are transmitted from rats or other rodents. Only a few patients worldwide are diagnosed with RBF annually. RBF can be fatal if left untreated, with a mortality rate of about 10% in patients with severe RBF.
CASE REPORT: A case 37-year-old previously healthy man presented to the emergency department with acute gastroenteritis, sepsis and multi-organ failure requiring ventilatory support. He was later diagnosed with RBF due to Streptobacillus moniliformis. He recovered rapidly after administration of intravenous penicillin G and was discharged from the hospital 10 days later.
CONCLUSIONS: This report describes a patient with RBF and multi-organ involvement requiring ventilatory support. He was successfully treated with intravenous penicillin G. To our knowledge, this is the first report of a patient from Qatar with RBF.

Keywords: Moniliformis, Penicillin G, Rat-Bite Fever, Zoonoses