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Medical Science Monitor Basic Research


Giant Cavernous Hemangioma of the Liver in a Patient with Autosomal Dominant Polycystic Kidney Disease

Congenital defects / diseases, Rare co-existance of disease or pathology

Iuliana Maria Ghenu, Rodica Constantin, Dorin Ionescu, Dorin Dragos

Romania Department of Pharmacology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Am J Case Rep 2020; 21:e927188

DOI: 10.12659/AJCR.927188

Available online: 2020-10-05

Published: 2020-11-18


BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is frequently associated with liver cysts, but an association with giant cavernous liver hemangioma is not mentioned in the literature.
CASE REPORT: We report the case of a 41-year-old man with ADPKD, secondary arterial hypertension, and stage 4 chronic kidney disease who presented with a 2-week history of persistent pain at the base of the right hemithorax and in the right hypochondrium. An ultrasound examination and a contrast-enhanced computed tomography scan revealed a giant cavernous liver hemangioma. Surgery was intially taken into account (however, twice delayed because of the COVID-19 pandemic) but later refused because it would have left the patient with dangerously few liver parenchyma.
CONCLUSIONS: To our knowledge, this is the first reported case of ADPKD associated with cavernous liver hemangioma. Vascular endothelial growth factor could be the pathophysiological link between the 2 conditions. Further research may unravel the molecular biology that underlies this possible association, pointing to new therapeutic avenues for ADPKD.

Keywords: Hemangioma, Cavernous, Polycystic Kidney, Autosomal Dominant, Vascular Endothelial Growth Factors