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Medical Science Monitor Basic Research


A Case of Recurrent Cervical Lymphadenopathy Due to Kikuchi-Fujimoto Disease

Unusual clinical course

Aliaa Alsolami, Rayan Altirkistani, Sarah Tayeb, Tariq Albeshri, Osama Estaitieh, Nada Rabie, Rehab Fadag, Mohammed Samannodi

Saudi Arabia Department of Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia

Am J Case Rep 2021; 22:e928760

DOI: 10.12659/AJCR.928760

Available online: 2020-12-30

Published: 2021-02-15


BACKGROUND: Kikuchi-Fujimoto (KFD) disease is a rare benign syndrome of necrotizing lymphadenopathy with distinctive histologic characteristics and was first reported in 1972. It is usually manifested by painful cervical lymphadenopathy and fever in young people, predominantly in females. KFD is a self-limiting disease and recurrence is rare.
CASE REPORT: We present the case of a middle-aged woman who presented with recurrent cervical lymphadenopathy 3 times in 13 years. Diagnosis of KFD was made by excisional lymph node biopsy, showing typical histopathologic features. She was treated with oral prednisone, with a favorable response.
CONCLUSIONS: In patients with recurrent lymphadenopathy, excisional biopsy can lead to definitive diagnosis and directed treatment. KFD is an uncommon and potential cause for recurrent lymphadenopathy.

Keywords: Histiocytic Necrotizing Lymphadenitis, Histiocytosis, Sinus, Image-Guided Biopsy