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Medical Science Monitor Basic Research


A 34-Year-Old Woman with a Diamniotic Dichorionic Twin Pregnancy Presenting with an Erythematous and Papular Skin Rash Associated with SARS-CoV-2 Infection

Liliana Oropeza Chávez, Ángel Sánchez Tinajero, José Arturo Martínez Orozco, Eduardo Becerril Vargas, Alfredo Dolores De la Merced, Danna Patricia Ruíz Santillán, Andrea Iraís Delgado Cueva, Nestor Alvarado Peña

Mexico Department of Reproductive Biology, UMARE Reproduction Clinic, Mexico City, Mexico

Am J Case Rep 2021; 22:e929489 :: DOI: 10.12659/AJCR.929489

Available online: 2021-02-11, In Press, Corrected Proof

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The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


BACKGROUND The damage caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has been extensive. Pregnant women are a group requiring special attention in medicine given the anatomical and physiological changes that occur during pregnancy. Skin rash is commonly associated with pregnancy, with the most common form of an erythematous maculopapular rash being pruritic urticarial papules and plaques of pregnancy. Skin rash is also an increasingly reported initial presentation in patients with coronavirus disease 2019 (COVID-19), due to infection with SARS-CoV-2.
CASE REPORT A 34-year-old woman with a diamniotic dichorionic twin pregnancy presented with clinical picture characterized by dermatological manifestations, namely an erythematous and papular skin rash associated with SARS-CoV-2 infection. A real-time reverse transcription-polymerase chain reaction (GeneFinder) test was positive for SARS-CoV-2 detection.
CONCLUSIONS Ten months after the onset of this pandemic, there is no conclusive evidence indicating that pregnant women represent a sector more or less vulnerable to severe forms of COVID-19 than the general population. This report has highlighted the importance of performing a reliable diagnostic test for SARS-CoV-2 infection in patients who present with a skin rash, particularly pregnant women.

Keywords: COVID-19; Insemination, Artificial; Pregnancy Complications