14 January 2021: Articles
Tissue Plasminogen Activator-Induced Angioedema Involving a Posterior Cerebral Artery Infarct: A Case Presentation
Unusual clinical course, Unusual or unexpected effect of treatment, Rare disease, Adverse events of drug therapy
Shahnaz Duymun E* , Vidhya Reddy E , Emma Bentley E , Anjali Bose-Kolanu EDOI: 10.12659/AJCR.927137
Am J Case Rep 2021; 22:e927137
Table 1. Comparison of studies involving tissue plasminogen activator-associated angioedema, highlighting the location of stroke and concomitant angiotensin-converting enzyme (ACE) inhibition.
| Study | Number of tPA-treated stroke patients | Angioedema post-thrombolysis | Concomitant ACE-inhibition* | Locations of Infarct (n) |
|---|---|---|---|---|
| Myslimi et al. []4 | 923 | 20 | 9 | MCA (18) |
| Lin et al. []11 | 559 | 5 | 2 | MCA (5) |
| Engelter et al. []9 | 120 | 2 | 1 | Insular |
| Frohlich et al. []3 | 136 | 15 | 10 | Primarily MCA |
| Correia et al. []12 | 236 | 8 | 5 | MCA (3); Frontal (1); Basal Ganglia (1); Others (3) |
| Hill et al. []13 | 176 | 9 | 7 | MCA/Insula (7); Brainstem (1) |
| Yayan []1 | n.s. | 41 | 24 | MCA (18); Insular (3); Others (3); Not mentioned (17) |
| Sczepanski and Bozyk []5 | 147 | 4 | 3 | MCA (3); PCA (1) |
| Hurford et al. []10 | 530 | 42 | 24 | ACA (38); Lacunar (3); PCA (1) |
| ACA – anterior cerebral artery; MCA – middle cerebral artery; n – number of infarcts in listed location correlating to number of patients with angioedema after thrombolysis in a given study; n.s. – not specified; PCA – posterior cerebral artery. * Number of patients using ACE inhibitors that developed angioedema after thrombolysis. | ||||