28 October 2020: Articles
Severe COVID-19 Pneumonia in a 30-Year-Old Woman in the 36 Week of Pregnancy Treated with Postpartum Extracorporeal Membrane Oxygenation
Unusual clinical course, Unusual or unexpected effect of treatment, Educational Purpose (only if useful for a systematic review or synthesis)
Wataru Takayama A* , Akira Endo A , Junichiro Yoshii B , Hirokuni Arai D , Keiji Oi C , Eiki Nagaoka C , Satoshi Toyama C , Hiroto Yamamoto C , Tokujiro Uchida D , Yasuhiro Otomo CDOI: 10.12659/AJCR.927521
Am J Case Rep 2020; 21:e927521
Table 1. Clinical laboratory results and the dose of heparin sodium.
| Variables | Reference range | HD 1 | HD 3 | HD 5 | HD 7 | HD 9 | HD 11 | HD 13 | HD 15 | HD 17 | HD 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ECMO therapy | |||||||||||
| – | 9.8 | 22.7 | 22.7 | 22.7 | 25.8 | 12.1 | 11.4 | 7.8 | – | – | |
| White blood cells(/μl) | 3300–8600 | 10400 | 7500 | 5500 | 5200 | 5500 | 5200 | 8400 | 9200 | 9600 | 7200 |
| Hemoglobin(g/dl) | 13.7–16.8 | 9.4 | 8.6 | 8.7 | 10.5 | 10.6 | 10.8 | 10.5 | 10.7 | 10.4 | 8.0 |
| Platelets(×10/μl) | 13.0–35.0 | 20.1 | 28.5 | 33.8 | 44.8 | 24.9 | 16.1 | 14.2 | 6.5 | 10.4 | 8.0 |
| Albumin (g/dl) | 4.1–5.1 | 1.4 | 1.4 | 1.5 | 2.0 | 4.3 | 4.4 | 4.5 | 4.3 | 4.0 | 3.5 |
| Urea nitrogen (mg/dl) | 8.0–20.0 | 5 | 12 | 13 | 12 | 21 | 49 | 53 | 58 | 40 | 13 |
| Serum creatinine (mg/dl) | 0.65–1.07 | 0.49 | 0.50 | 0.49 | 0.44 | 0.43 | 0.46 | 0.41 | 0.39 | 0.36 | 13 |
| Total bilirubin (mg/dl) | 0.4–1.5 | 0.4 | 0.3 | 0.3 | 0.3 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 |
| C-reactive protein (mg/dl) | 0.00–0.14 | 18.86 | 7.40 | 8.72 | 7.89 | 1.25 | 0.36 | 0.15 | 0.12 | 0.07 | 0.09 |
| Prothrombin time (%) | 75–12– | 89.1 | 54.6 | 75.3 | 79.1 | 69.2 | 79.1 | 86.7 | 65.4 | 89.1 | 98.6 |
| International normalized ratio | 0.85–1.15 | 1.07 | 1.40 | 1.16 | 1.13 | 1.22 | 1.13 | 1.08 | 1.26 | 1.06 | 1.01 |
| Activated partial thrombin time (s) | 24.0–39.0 | 38.9 | 32.9 | 35.1 | 43.2 | 46.9 | 58.7 | 40.2 | 43.1 | 26.6 | 27.5 |
| Fibrinogen (mg/dl) | 200–400 | 422 | 402 | 349 | 376 | 240 | 177 | 176 | 45 | 145 | 176 |
| Fibrin/fibrinogen degradation products (μg/ml) | 2.0–8.0 | 8.8 | 10.4 | 6.0 | 12.4 | 19.9 | 13.1 | 9.1 | 230.3 | 43.0 | 5.3 |
| D-dimer (μg/ml) | 4.42 | 5.04 | 2.43 | 6.81 | 13.68 | 10.64 | 4.68 | 43.43 | 10.83 | 2.36 | |
| Antithrombin activity (%) | > 80.0 | – | 84.2 | – | 85.0 | – | 84.1 | – | 100.8 | – | – |
| Activated clotting time (s) | 90–120 | 164 | 199 | 241 | 232 | 210 | |||||
| HD – hospital day; ID – illness day; ECMO – extracorporeal membrane oxygenation. | |||||||||||