09 April 2021: Articles
False-Positive Nonstructural Protein 1 Antigen in a Patient with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Case Report with Literature Review
Mistake in diagnosis
Supat Chamnanchanunt A* , Pravinwan Thungthong A , Asrinda Abdulkanan B , Chajchawan Nakhakes ADOI: 10.12659/AJCR.928865
Am J Case Rep 2021; 22:e928865
Table 1. Clinical parameters of 3 hematologic malignancy patients with a false-positive dengue NS1 test result.
| Clinical parameters | Our case | Patient 1 | Patient 2 |
|---|---|---|---|
| Duration of fever (days) | 3 | 30 | 3 |
| Additional symptoms | Myalgia, weight loss | Unremarkable | Myalgia |
| Comorbidity disease(s) | No | Hypertension, diabetes mellitus | Hypertension, dyslipidemia |
| Physical examination | |||
| Body temperature (oC) | 39.0 | 38.9 | 40.0 |
| Organomegaly | Hepatosplenomegaly | No | No |
| Lymphadenopathy | Yes | No | No |
| CBC | |||
| Hemoglobin (g/dL) | 9.6 | 9.7 | 5.8 |
| White blood cells count (cells/mm) | 3300 | 2,500 | 43,400 |
| Blast cells (%) | 70 | N/A | 3 |
| Platelets count (cells/mm) | 7000 | 101,000 | 140,000 |
| LFT | |||
| AST (U/L) | 102 | 156 | N/A |
| ALT (U/L) | 141 | 75 | N/A |
| Detection of dengue | |||
| Dengue NS1 | Positive | Positive | Positive |
| Dengue IgM | Negative | Negative | Negative |
| Dengue IgG | Positive | Negative | Negative |
| Dengue RT-PCR (performed date) | Not detected (5 day) | Not detected | Not detected (4 day) |
| Type of hematologic malignancy | B cells – acute lymphoblastic leukemia (Ph+) | Aggressive natural killer cell lymphoma | Acute myeloid leukemia |
| CBC – complete blood count; LFT – liver function test; AST – aspartate aminotransferase; ALT – alanine aminotransferase: N/A – not available. | |||