12 August 2021>: Articles
Hepatotoxicity Induced by Fluvastatin: A Reversible Acute Cholestatic Liver Injury
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy
Najah S. Alanazi A , Tahani S. Alenazi A , Khalidah A. Alenzi A*DOI: 10.12659/AJCR.931418
Am J Case Rep 2021; 22:e931418
Table 2. Naranjo Causality Scale for adverse drug reactions.
Fluvastatin | Metformin | Gliclazide | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
No | Question/Scoring Yes/No/Do Not Know Or Unavailable | Yes | No | NA | Yes | No | NA | Yes | No | NA |
1 | Are there previous conclusive reports on this reaction? 1/0/0 | +1 | +1 | +1 | ||||||
2 | Did the adverse event appear after the suspected drug was given? 2/−1/0 | +2 | −1 | −1 | ||||||
3 | Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given? 1/0/0 | +1 | +1 | +1 | ||||||
4 | Did the adverse reaction reappear when the drug was readministered? 2/−1/0 | 0 | 0 | 0 | ||||||
5 | Are there alternative causes that could have caused the reaction? −1/2/0 | +2 | +2 | +2 | ||||||
6 | Did the reaction reappear when a placebo was given? −1/1/0 | 0 | 0 | 0 | ||||||
7 | Was the drug detected in any body fluid in toxic concentrations? 1/0/0 | 0 | 0 | 0 | ||||||
8 | Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? 1/0/0 | 0 | 0 | 0 | ||||||
9 | Did the patient have a similar reaction to the same or similar drugs in any previous exposure? 1/0/0 | 0 | 0 | 0 | ||||||
10 | Was the adverse event confirmed by any objective evidence? | +1 | +1 | +1 | ||||||
Scoring >9 – highly probable ADR; 5–8 – probable ADR; 1-4 – possible ADR; 0 – unlikely ADR. |